| Data | In casa | Ospite | Risultato |
|---|---|---|---|
| 11/12/25 18.45 | FC Midtjylland | KRC Genk | 1:0 |
| 11/12/25 18.45 | PFC Ludogorets Razgrad | PAOK Salonicco | 3:3 |
| 11/12/25 18.45 | FC Utrecht | Nottingham Forest | 1:2 |
| 11/12/25 18.45 | Ferencvaros Budapest | Glasgow Rangers | 2:1 |
| 11/12/25 18.45 | Young Boys Berna | OSC Lille | 1:0 |
| 11/12/25 18.45 | VfB Stoccarda | Maccabi Tel Aviv | 4:1 |
| 11/12/25 18.45 | Dinamo Zagabria | Real Betis Siviglia | 1:3 |
| 11/12/25 18.45 | SK Sturm Graz | Stella Rossa Belgrado | 0:1 |
| 11/12/25 18.45 | OGC Nizza | Sporting Braga | 0:1 |
| 11/12/25 21.00 | FC Porto | Malmö FF | 2:1 |
| 11/12/25 21.00 | FC Basilea | Aston Villa | 1:2 |
| 11/12/25 21.00 | Olympique Lione | Go Ahead Eagles Deventer | 2:1 |
| 11/12/25 21.00 | Panathinaikos Atene | Viktoria Pilsen | 0:0 |
| 11/12/25 21.00 | SC Friburgo | FC Red Bull Salisburgo | 1:0 |
| 11/12/25 21.00 | FCSB Bukarest | Feyenoord Rotterdam | 4:3 |
| 11/12/25 21.00 | Celta Vigo | Bologna | 1:2 |
| 11/12/25 21.00 | Celtic Glasgow | Roma | 0:3 |
| 11/12/25 21.00 | Brann Bergen | Fenerbahce Istanbul | 0:4 |